SoHo is a neighborhood that has been about to lose its cool for thirty years and somehow keeps the cast-iron facades and the $600 sneakers. The restaurants follow the same logic: very pretty, very sure of themselves, and a fair number of them will hand you a menu that is mostly pasta and bread and then look surprised when you ask a follow-up question. This list is the places here that actually handle gluten-free well. A good place to start is Senza Gluten by Jemiko, where the whole kitchen is gluten-free, or Casa 13urger for gluten-free fried food. For more, our picks for pizza and breakfast and brunch cover more ground, and Nolita next door has its own list.
Updated Oct 6, 2026
Fully gluten-free bakery with clear labeling, dedicated protocols, and consistently excellent reviews from gluten-free diners.
Fully gluten-free bakery with clear labeling, dedicated protocols, and consistently excellent reviews from gluten-free diners.
CleanPlate Weekly
The safest gluten-free spots in NYC — a few hand-picked places in your inbox each week.
Italian
Solid gluten-free choice with marked menu items, ample pasta and pizza options, and generally knowledgeable staff; most recent reviews are positive and note careful preparation, though there is no dedicated fryer or facility.
Solid gluten-free choice with marked menu items, ample pasta and pizza options, and generally knowledgeable staff; most recent reviews are positive and note careful preparation, though there is no dedicated fryer or facility.
CleanPlate Weekly
The safest gluten-free spots in NYC — a few hand-picked places in your inbox each week.