SoHo is a neighborhood that has been about to lose its cool for thirty years and somehow keeps the cast-iron facades and the $600 sneakers. The restaurants follow the same logic: very pretty, very sure of themselves, and a fair number of them will hand you a menu that is mostly pasta and bread and then look surprised when you ask a follow-up question. This list is the places here that actually handle gluten-free well. A good place to start is Senza Gluten by Jemiko, where the whole kitchen is gluten-free, or Casa 13urger for gluten-free fried food. For more, our picks for pizza and breakfast and brunch cover more ground, and Nolita next door has its own list.
Updated Oct 6, 2026
American
Nearly the entire menu can be made gluten-free, including burgers, fried chicken, fries, and mozzarella sticks, with clear labeling and highly positive recent reviews. Dedicated gluten-free fries and buns are available, making this a standout option for gluten-free diners.
Nearly the entire menu can be made gluten-free, including burgers, fried chicken, fries, and mozzarella sticks, with clear labeling and highly positive recent reviews. Dedicated gluten-free fries and buns are available, making this a standout option for gluten-free diners.
CleanPlate Weekly
The safest gluten-free spots in NYC — a few hand-picked places in your inbox each week.
Italian
Solid gluten-free choice with marked menu items, ample pasta and pizza options, and generally knowledgeable staff; most recent reviews are positive and note careful preparation, though there is no dedicated fryer or facility.
Solid gluten-free choice with marked menu items, ample pasta and pizza options, and generally knowledgeable staff; most recent reviews are positive and note careful preparation, though there is no dedicated fryer or facility.
CleanPlate Weekly
The safest gluten-free spots in NYC — a few hand-picked places in your inbox each week.
